Last edited by Samutaxe
Sunday, August 9, 2020 | History

6 edition of Molecular Mechanisms of Pathogenesis in Chagas" Disease found in the catalog.

Molecular Mechanisms of Pathogenesis in Chagas" Disease

by John M. Kelly

  • 146 Want to read
  • 32 Currently reading

Published by Springer .
Written in English

    Subjects:
  • Immunology,
  • Infectious & contagious diseases,
  • Medical,
  • Medical / Nursing,
  • Life Sciences - Biology - Molecular Biology,
  • Parasitology,
  • Tropical Medicine,
  • Genetics,
  • Medical / Immunology,
  • Medical / Infectious Diseases,
  • Medical / Parasitology,
  • Medical : Tropical Medicine,
  • Science : Life Sciences - Biology - Molecular Biology,
  • Pathology,
  • Chagas Disease,
  • Chagas" disease,
  • Molecular Biology,
  • Molecular aspects,
  • Pathogenesis,
  • etiology

  • Edition Notes

    Medical Intelligence Unit

    The Physical Object
    FormatHardcover
    Number of Pages172
    ID Numbers
    Open LibraryOL10325091M
    ISBN 100306478498
    ISBN 109780306478499

    Molecular mechanisms of myocarditis caused by Trypanosoma cruzi. Indeed, the pathogenesis of Chagas disease is intricate and multifactorial, and the roles of the parasite and the immune response in initiating and maintaining the disease are still controversial. Chagas’ heart disease typically kills people in the age range of 30 to 50 years. The disease is considered incurable, and its high mor-tality rates translate to hundreds of thousands of deaths per year (). Perhaps the most important problem in Chagas’ disease is the determination of its pathogenesis (). (Refer-Cited by:

    Pathogenesis of Chagas’ myocarditis Milei et al. proposed a combined theory that could explain the pathogenic mechanism in chronic chagasic myocarditis (Milei, et Author: Julián González, Roberto Guerri-Guttenberg, Daniel Grana, Francisco Azzato, José Milei. Pathology and pathogenesis of Chagas disease. molecular self-mimicry by parasite antigens, or cryptic epitopes shared by the host and parasites -have also .

    Carlos Chagas > years ago, much has been learned about Ch agas disease pathogenesis; however, the outcome of T. cruzi infection is highly variable and dif fi cult to predict. Many mechanisms have. Chagas disease, caused by the protozoan Trypanosoma cruzi, has a variable clinical course, ranging from symptomless infection to severe chronic disease with cardiovascular or gastrointestinal involvement or even overwhelming acute factors influencing this clinical variability have not been elucidated, but genetic variation of both the host and parasite Cited by:


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Molecular Mechanisms of Pathogenesis in Chagas" Disease by John M. Kelly Download PDF EPUB FB2

Chagas' disease, which results from infection with the single cell parasite Trypanosoma cruzi, is a debilitating condition that is a major problem in many parts of Latin technical progress is now facilitating dissection of the molecular mechanisms of disease pathogenesis, a process that will ultimately provide new strategies to alleviate the enormous public health.

Chagas' disease, which results from infection with the single cell parasite Trypanosoma cruzi, is a debilitating condition that is a major problem in many parts of Latin America. Rapid technical progress is now facilitating dissection of the molecular mechanisms of disease pathogenesis, a process that will ultimately provide new strategies to alleviate the enormous public health Format: Hardcover.

ISBN: OCLC Number: Description: pages: illustrations ; 24 cm. Contents: Genetic Diversity of Trypanosoma cruzi and the Epidemiology of Chagas Disease / Michael A. Miles, Matthew Yeo and Michael Gaunt --Distinct Mechanisms Operate to Control Stage-Specific and Cell-Cycle Dependent Gene Expression in Molecular Mechanisms of Pathogenesis in Chagas Disease book.

Molecular Mechanisms of Pathogenesis in Chagas Disease John Morrison Kelly Chagas' disease, which results from infection with the single cell parasite Trypanosoma cruzi, is a debilitating condition that is a major problem in many parts of Latin America.

Chagas disease, caused by the obligate unicellular parasite Trypanosoma cruzi, presents itself in a diverse collection of clinical manifestations, ranging from severe, fatal heart and digestive tract pathologies to unapparent or minor alterations that do not compromise survival.

Over the years, a number of mechanisms have been proposed to explain the pathogenesis Cited by: Mechanisms of pathogenesis in Chagas disease F elipe Kierszenbaum Department of Microbiology and Molecular Genetics, Michigan State University. The epidemiology of T. cruzi and Chagas heart disease and the varied mechanisms leading to myocyte destruction, mononuclear cell infiltration, fibrosis, and edema in the heart have been extensively studied by hundreds of scientists for more than by: Chagas heart disease (CHD), caused by the protozoan parasite Trypanosoma cruzi, is the leading cause of infectious myocarditis in the world.

The etiology of CHD is unclear and multiple mechanisms have been proposed to explain the pathogenesis of the by: Despite more than years of study, we still lack a precise understanding of the molecular events involved in this cardiomyopathy.

Bonney and Engman 9 very nicely summarize the proposed contributory mechanisms, including the two best studied: parasite persistence and autoimmunity. Their review includes a scholarly and balanced treatment of the history of autoimmunity research in Chagas heart : James M.

Musser, Frank R. DeLeo. The functional roles of particular chemokines and other chemokine receptors in host resistance to infection and in the pathogenesis of Chagas disease remain to be investigated in mouse model.

The T. cruzi-infected rats have also been used to model the human disease. Chagas' disease, which results from infection with the single cell parasite Trypanosoma cruzi, is a debilitating condition that is a major problem in many parts of Latin America.

Rapid technical progress is now facilitating dissection of the molecular mechanisms of disease pathogenesis, a process that will ultimately provide new strategies to alleviate the enormous public health. Molecular mimicry between parasite and host antigens may also contribute to Chagas pathogenesis by driving a deleterious autoimmune response, as has been demonstrated for experimental autoimmune encephalomyelitis (EAE), a better understood model of autoimmune pathology induced by molecular mimicry that is a surrogate for studying aspects of multiple sclerosis pathogenesis in humans.

40 The potential to extend the knowledge of autoimmunity in Chagas disease Cited by: ISBN: OCLC Number: Description: 1 online resource ( pages): illustrations: Contents: Genetic Diversity of Trypanosoma cruzi and the Epidemiology of Chagas Disease / Michael A.

Miles, Matthew Yeo and Michael Gaunt --Distinct Mechanisms Operate to Control Stage-Specific and Cell-Cycle Dependent Gene Expression. The protozoan parasite Trypanosoma cruzi, the etiologic agent of Chagas disease, is an obligate intracellular protozoan pathogen.

Overlapping mechanisms ensure successful infection, yet the relationship between these cellular events and clinical disease remains by: M. Hontebeyrie-Joskowicz and P. Minoprio Pathogenesis of Chagas' disease Z.A. Andrade (*) Gonealo Moniz Research Center, FIOCRUZ, Salvador, Bahia (Brazil) Introduction Immunological processes prob- ably play a fundamental role in the pathogenesis of Chagas' disease.

Evidence for this is mostly ob- tained from experimental by:   Chagas disease is a potentially life threatening condition that was historically mainly endemic to Latin America. Over the last decade, however, the disease has spread to and is increasingly prevalent in other continents such as North America and Europe, with an estimated 7 million people infected worldwide.

It is primarily transmitted by insect vectors that carry the. This book offers a comprehensive overview of Chagas disease, including its vectorial and congenital transmission, as well as molecular diagnosis, which is essential for screening. Pathogenesis of the disease and the development of timely, effective anti-trypanosomal treatments are discussed.

Books Neisseria: Molecular Mechanisms of Pathogenesis Full Download. Galahad. Biopheat. [PDF] Molecular Mechanisms of Pathogenesis in Chagas' Disease (Medical Intelligence Unit) Full.

Patricia Beck. Read Fungal Pathogenesis in Plants and Crops: Molecular Biology and Host Defense Mechanisms. Alviena1 Bella1. For these reasons, Chagas disease is best considered a collection of related but distinct illnesses.

This review highlights the pathology and pathogenesis of the most common adverse sequela of T. cruzi infection-Chagas heart disease-and concludes with a discussion of key unanswered questions and a view to the by: Chagas heart disease (CHD), caused by the protozoan parasite Trypanosoma cruzi, is the leading cause of infectious myocarditis in the world.

The etiology of CHD is unclear and multiple mechanisms. Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the.

Acute Trypanosoma cruzi infections can be asymptomatic, but chronically infected individuals can die of Chagas' disease.

The transfer of the parasite mitochondrial kinetoplast DNA (kDNA) minicircle to the genome of chagasic patients can explain the pathogenesis of the disease; in cases of Chagas' disease with evident cardiomyopathy, the kDNA minicircles Cited by: 1.

Trypanosoma cruzi and Chagas disease. Trypanosoma cruzi is a single-celled eukaryotic parasite with a complex life cycle involving several stages in both mammals and blood-sucking triatomine bugs.

Transmission of T. cruzi to humans may occur when bug excreta, contaminated with the infective, flagellated trypomastigote form of the parasite and released by the bug while Cited by: